Vitamin D is an indispensable compound for the development and maintenance of proper bone composition. More and more studies point to the beneficial properties of psoriasis, besides its beneficial effect on bone, in the therapy of tumors.
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- Szemйlyleнrбs: It occurs in two forms in nature. It is a part of several multivitamin supplements in the form of supplemental vitamin D, ergocalciferol (D2) or cholecalciferol (D3).
- Locations: In Vitamin D, the UV-B constituents of sunlight come from the skin (7-dehydrocholesterol) and come from the diet (fish, fish oils). He makes regular visits to the liver where he enriches the 25-atom with a hydroxyl group and then enters the kidney where he places another hydroxyl group on the 1-or 24-atom.
- After "cosmetic" strokes, your protein bud begins to circulate and reaches your target cells, where you work through receptors.
- Active vitamin D enhances the absorption of calcium and phosphate, regulates the function of bone and bone-germ cells, helps to create the proper composition of bone, bone mineral.
- Tulajdonsбgai: Presumably it has anti-osteoporotic, immunomodulatory, anti-tumor, antioxidant effect. It works well for psoriasis.
- Where to Find It Last: Vitamin D and its metabolites are primarily found in the bile. The most enduring products are the kidneys.
How Much Vitamin D Do I Need?Catch request, the answer is complete. Vitamin D is an essential vitamin in healthy bones. In the United States and Canada, the recommended daily intake of vitamin D for children and young adults is 200 International Units (IU) and 400 IU for the elderly (51-70 years), and for those over 70, this value is 600NE йrdekйben. In some European countries, the standard dose for people over 65 is 400 IU per day, which is the same as the recommended dose of Vitamin D for all ages in the US Food and Drug Administration. In Hungary, over 50 years, 600-800 IU of vitamin D is suggested. However, there are resolutions in which 1000 IU per day is controlled.
The D-vitaminhiбny kialakulбsбnak veszйlye rose kizбrуlagosan breastfed csecsemхk, idхsek, little tartуzkodу day szemйlyek the sцtйtebb bхrszнnnel rendelkezх people zsнrfelszнvуdбsi complaints (gyulladбsos bйlbetegsйgekkel) йlх patients krуnikus mбjbetegsйg, vesebetegsйg йs hasnyбlmirigy-elйgtelensйg, alcoholism fennбllбsa esetйben. Interestingly, a 70-year-old man consumes an average of 4 times less vitamin D over the skin compared to a 20-year-old. The level of calcium absorption also decreases with age. Patients in higher risk groups may receive vitamin D treatment under medical supervision.
Vitamin Bone EnhancementVitamin D is effective in preventing osteoporosis, helping to release calcium and phosphate into the bones, contributing to the healthy development of the bones. The bone effect is based on the fact that bone mineralization is a mediated phenomenon of vitamin D, in which calcium and phosphate metabolism are regulated by the linking link. Numerous research has shown that there is a correlation between low serum levels of vitamin D and the occurrence of osteoarthritis and osteoporosis. The Framingham study clearly indicates that low dietary intake of vitamin D is associated with progression of osteoarthritis in the space. At the moment, we cannot equate the development of osteoporosis with vitamin D deficiency. Vitamin D deficiency can lead to osteoporosis, which is more a matter of bone mineralization than a common cause of bone loss, which is characteristic of osteoporosis. However, they are all prone to bone fractures.
A convincing overwhelming number of studies on the effectiveness of vitamin D treatment in the treatment of osteoporosis are the positive results obtained from bone marrow measurements. At standard daily doses of more than 400 IU (700-800 IU), a three-year, placebo-controlled, randomized (randomized) study was performed with calcium supplementation. In the elderly at home with fewer patients in the day, the number of drips has decreased as a result of treatment. Another study reported close to 400 men and women over the age of 65 years and positive changes in vitamin D-calcium therapy. The rate of bone loss slowed down and the incidence of osteoporosis decreased significantly.
Shortages and inventory surpluses also cause problemsDue to the deficiency of active vitamin D, calcium and phosphate absorption is impaired, which causes the parathyroid gland to produce an excess of parathyroid hormone (PTH) to normalize serum calcium. PTH moves more calcium and phosphate from the bone into the circulation.
Prolonged vitamin D deficiency in infants and children can lead to bone deformities due to mineralization disorders, the inadequate bone content of what is known in the literature as rickets. In adults, muscle weakness, bone pain and osteomalacia (osteoporosis) may develop. Least severe vitamin D deficiency prevents children and adolescents from achieving optimum genetically engineered peak bone mass. In adulthood, vitamin D deficiency leads to increased parathyroid hormone (hyperparathyroidism), high levels of parathyroid hormone, and a tendency to bone loss in many people's everyday lives.
Vitamin D in oil or tablet form is a remedy for childhood angina and adult bone marrow. In such a course, the doctor has set very high initial doses, and only gradually focuses on smaller amounts for sustained treatment. It is now generally accepted that infants and the few who are few days away for prevention should receive regular vitamin D treatment.
The other side of the food is overdosing on vitamin D. The fat-rich amount of vitamin A is stored in the body, and at very high daily doses (10-100 times the usual dose), it can cause symptoms of poisoning. Signs of overdose may include loss of vision, nausea, vomiting, bone pain, constipation, weakness, and urinary problems. Early symptoms include deterioration of kidney function, weight loss, calcium deposition, calcification in the extra-bone organs. Vitamin D can be stored in the body for weeks to months, so if you stop taking it, the symptoms of poisoning may persist for a while.
Jуban thinBile acid resins such as cholestyramine and colestipol may reduce the absorption of vitamin D, which may result in a loss of potency or possibly deficiency symptoms. Ketoconazole, which has antifungal activity, does not inhibit vitamin D, and serum levels of its active form of vitamin D are decreased following ketoconazole administration. Magnesium-containing acid binders should not be taken with vitamin D supplements because of the risk of high magnesium levels in the blood. They inhibit the activity of phenobarbital and phenytoin, which has a sedative or anti-epileptic effect, reduces the level of vitamin D in the liver, which is responsible for the conversion of vitamin D, which is responsible for vitamin A conversion. Light oils, such as paraffin oil for laxative use, can also inhibit the absorption of fatty vitamins such as vitamin D. Stripping creams also negatively affect the body's vitamin D supply.
Taking high-dose, calcium-containing vitamin D increases the effectiveness of therapy in, among others, osteoporosis-induced corticosteroids.
Supplemental vitamin D therapy should only be used under the explicit supervision and supervision of a physician if the patient is taking glycosides that are effective for the heart. High calcium levels can induce heart arrhythmias with digoxin intake. The likelihood of very high calcium levels is particularly high when you are also taking diuretic thiazide derivatives in addition to vitamin D.
Looking out over the boneThe role of vitamin D in preventing and successfully treating other diseases is currently the subject of intensive research.
- High blood pressure preceded the use of calcipotriol, an artificial derivative of vitamin D, in the therapy of mild to severe psoriasis. It is based on the fact that the active ingredient is involved in the growth and development of skin cells. Calcipotriol reduces the density of psoriasis and the size of the affected area. The ointment can only be used if less than 35% of the body surface is affected.
- The other synthetic form, doxercalciferol, has been associated with high levels of parathyroid hormone secondary to chronic kidney disease involved in dialysis.
- Deltanoids are vitamin D analogues that, when developed and tested clinically, are likely to bring about a red blood cell transformation in chemotherapy. These analogues have been shown to have cell growth regulatory, antiproliferative and cellular differentiation effects. Due to the suspected anticancer activity, vitamin D analogues may play a role in the thickening of breast, breast, and prostate tumors, although for the time being they are in experimental form only.